Top-Bac® consists in a proprietary patented expression cassette composed by several genetic regulatory elements working in cascade. When incorporated into the genome of a baculovirus vector, improves to unprecedented levels the productivity and quality of recombinant proteins produced by host cells.
Apoptosis inhibition (Sf IAP)
Top-Bac® is fully compatible with the most common baculovirus vector-based production technologies, and consistently provides to the system up to 400% increase in production yields in insect cells above current industry standards. Additionally, Top-Bac® also improves product quality by reducing foreign protein proteolysis.
Top-Bac® has been tested for the production of a variety of proteins in insect cells and insects (CrisBioTM technology), increasing productivities in both platforms.