Algenex’ core expertise is in the production of biologics using Baculovirus vectors.
Baculovirus Expression Vector Systems (BEVS) are one of the most powerful, robust and versatile eukaryotic expression systems, significantly increasing the speed and versatility of expression of a wide variety of protein families allowing the acceleration of development times of protein-based pharmaceutical or diagnostic products.
CrisBio® and Topbac® are propietary, patent protected technologies which can be applied in combination or on a stand-alone basis.
Improved baculovirus vectors
Proprietary Baculovirus expression cassette that allows significant yield increases, long-lasting expression and reduces protein proteolysis.Learn more
Disruptive manufacturing process
Harnessing the power of insects to act as natural single-use bioreactors with chrysalises from the Trichoplusia ni Lepidopter as production tool.Learn more
Current production methods for recombinant proteins present a series of challenges in respect to development speed, scalability, technical complexity and cost.
CrisBio®, is an automated process that enables productivity of gram/litre levels with an extremely low investment and the upside of production flexibility and immediate scalability.
CrisBio® is a simple and robust process that has proven efficient in producing complex antigens.
CrisBio® uses pupae from the Trichoplusia ni, the natural host of the AcMNPV baculovirus vector used in the commercial vaccine production.
> than 1mg of purified recombinant protein per insect in average
- Simple manufacturing
- Almost unlimited linear scalability
- High versatility
- High efficiency: Incorporates TopBac® as productivity booster
- Significant savings in production costs
CrisBio® manufacturing process
TopBac® is a proprietary patented expression cassette that comprises several genetic regulatory elements working in cascade. When incorporated into the genome of a baculovirus vector, TopBac® significantly improves the productivity and quality of recombinant proteins produced by host cells. TopBac® is fully compatible with the most common baculovirus vector-based production technologies.